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Microfluidic devices — application in anticancer studies

Microfluidic devices — application in anticancer studies
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171.74 kB
Author:
Elżbieta Jędrych, Michał Chudy, Artur Dybko, Zbigniew Brzózka
Email:
ejedrych[at]ch[dot]pw[dot]edu[dot]pl
Date:
14 August 2013
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Abstract: A rapidly growing pharmaceutical industry requires faster and more effi cient ways to fi nd and test new drugs. One of the new method for cell culture and examining the toxic eff ects of drugs is application of microfl uidic systems. Th ey provide new types of microenvironments and new methods for investigation of anticancer therapy. Th e use of microsystems is a solution that gives the opportunity to reduce not only cost and time, but also a number of tests on animals. In this paper we present designed and fabricated hybrid microfl uidic systems which are applicable for cell culture, cell based cytotoxicity assays and photodynamic therapy procedures. Polydimethylsiloxane (PDMS) and sodium glass were used for fabrication of microdevices. Th e designed geometry of the microdevices includes cell culture microchambers and a concentration gradient generator (CGG). Th e CGG enables to obtain diff erent concentrations of tested drugs in a single step, which is a signifi cant simplifi cation of cytotoxicity assay procedure. In the designed microsystems three various cell lines (normal and carcinoma) were cultured and analyzed.

Keywords: microfl uidic system, PDMS, adherent cell culture, concentration gradient generator (CGG), cytotoxicity tests, photodynamic therapy (PDT) procedures

Area: Biomedical Engineering

BibTeX:

@article{Jedrych2012,
  author = {Elżbieta Jędrych and Michał Chudy and Artur Dybko and Zbigniew Brzózka},
  title = {Microfluidic devices — application in anticancer studies},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {3--5},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/83-microfluidic-devices-application-in-anticancer-studies}
}
 
 

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