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Preparation of chitosan/calcium phosphate based injectable system for guided bone regeneration and its properties investigation

Preparation of chitosan/calcium phosphate based injectable system for guided bone regeneration and its properties investigation
File Size:
540.37 kB
Author:
Grzegorz Bubak, Magdalena Kowalczyk, Tomasz Brynk, Witold Bojar, Martyna Kucharska, Tomasz Ciach
Email:
gbubak[at]gmail[dot]com
Date:
13 August 2013
Downloads:
3 x

 

Abstract: The main objective of the work was to design and fabricate an injectable biomaterial with osteoconductive properties that can be used in dental applications in peri-implant therapy concerning guided bone regeneration. For that purpose, a self-setting biomaterial consisting of chitosan/tricalcium phosphate microparticles and sodium alginate was formulated. The obtained material was characterized regarding microsphere and formed agglomerates morphology and microstructure. Physical properties, relating to setting time and mechanical properties, were also investigated. Finally, in vivo response to implanted biomaterial was studied on a rat model and compared with commercially available alloplastic material. Th e results showed that designed injectable biomaterial fulfi lled main requirements for guided bone regeneration application.

Keywords: chitosan, alginate, -tricalcium phosphate, injectable systems, guided bone regeneration, in vivo studies, biomaterial

Area: Mechanics, Automatics and Robotics

BibTeX:

@article{Bubak2011,
  author = {Grzegorz Bubak and Magdalena Kowalczyk and Tomasz Brynk and Witold Bojar and Martyna Kucharska and Tomasz Ciach},
  title = {Preparation of chitosan/calcium phosphate based injectable system for guided bone regeneration and its properties investigation},
  journal = {Challenges of Modern Technology},
  year = {2011},
  volume = {2},
  number = {4},
  pages = {21--26},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/62-preparation-of-chitosan-calcium-phosphate-based-injectable-system-for-guided-bone-regeneration-and-its-properties-investigation}
}
 
 

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