Pathways of tRNA turnover in eukaryotic cells

Pathways of tRNA turnover in eukaryotic cells
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Tomasz Wojciech Turowski
13 August 2013
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Abstract: Cell ability to control amount of a transfer RNA is one of the ways to regulate rate of protein synthesis. Because 80–90% dry mass of cells are proteins, the level of translation is determinant to the cell growth. Growth of cells is a key question in tumors therapy and biotechnology. tRNA turnover consist of a three pathways described in a last few years: exosome and TRAMP complex dependent pathway in nucleus, directed to hypomodifi ed or aff ected tRNA; rapid tRNA decay pathway involving two 5’–3’ exonucleases Rat1 and Xrn1, proposed to occur in nucleus and cytoplasm; stress-activated endonucleolytic cleavage to tRNA halves pathway, founded in cytoplasm with a clear role to direct regulation of translation by tRNA half-molecules inhibition

Keywords: tRNA turnover, rapid tRNA decay, polymerase III

Area: Natural Science


  author = {Tomasz Wojciech Turowski},
  title = {Pathways of tRNA turnover in eukaryotic cells},
  journal = {Challenges of Modern Technology},
  year = {2011},
  volume = {2},
  number = {2},
  pages = {63--65},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/36-pathways-of-trna-turnover-in-eukaryotic-cells}

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