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Volume 3, Year 2012, Issue 2, April-June

Volume 3, Year 2012, Issue 2, April-June

Microfluidic devices — application in anticancer studies
Author:
Elżbieta Jędrych, Michał Chudy, Artur Dybko, Zbigniew Brzózka
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9 x
 

 

Abstract: A rapidly growing pharmaceutical industry requires faster and more effi cient ways to fi nd and test new drugs. One of the new method for cell culture and examining the toxic eff ects of drugs is application of microfl uidic systems. Th ey provide new types of microenvironments and new methods for investigation of anticancer therapy. Th e use of microsystems is a solution that gives the opportunity to reduce not only cost and time, but also a number of tests on animals. In this paper we present designed and fabricated hybrid microfl uidic systems which are applicable for cell culture, cell based cytotoxicity assays and photodynamic therapy procedures. Polydimethylsiloxane (PDMS) and sodium glass were used for fabrication of microdevices. Th e designed geometry of the microdevices includes cell culture microchambers and a concentration gradient generator (CGG). Th e CGG enables to obtain diff erent concentrations of tested drugs in a single step, which is a signifi cant simplifi cation of cytotoxicity assay procedure. In the designed microsystems three various cell lines (normal and carcinoma) were cultured and analyzed.

Keywords: microfl uidic system, PDMS, adherent cell culture, concentration gradient generator (CGG), cytotoxicity tests, photodynamic therapy (PDT) procedures

Area: Biomedical Engineering

BibTeX:

@article{Jedrych2012,
  author = {Elżbieta Jędrych and Michał Chudy and Artur Dybko and Zbigniew Brzózka},
  title = {Microfluidic devices — application in anticancer studies},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {3--5},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/83-microfluidic-devices-application-in-anticancer-studies}
}
Development of a Point-of-Care system for early diagnostics of genetic diseases
Author:
Radosław Kwapiszewski, Michał Chudy, Artur Dybko, Zbigniew Brzózka
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3 x
 

 

Abstract: Lysosomal storage disorders (LSDs) represent a group of more than 45 genetically inherited diseases caused by the absence or defi ciency of one or more specifi c lysosomal enzymes. Nowadays, there is a lack of reports on fast, reliable methods for the diagnostics of LSDs. Currently applied diagnostic approaches generate many false-negative and false-positive results, which results in classifi cation of patients to inappropriate therapeutic groups. Moreover, these methods are time-consuming (even 20 hours), and are carried out only in a few laboratories in the world. Th e goal of this work was to develop a method and a tool, a Point-of-Care system, for diagnostics of LSDs. Th e polymeric microdevice consists of a cell lysis module, a mixing microchannel and an optical detection module. Th e system enables to determine the activity of -galactosidase (defi cient in Fabry disease), and to reduce the time of analysis to 10 min. Due to its easy fabrication steps and low price, it seems to be a prospective tool for a point-of-care approach.

Keywords: lysosomal storage disorders, Fabry disease, Gaucher disease, early diagnostics, intracellular enzyme activity, Point-of-Care system, lab-on-a-chip system

Area: Biomedical Engineering

BibTeX:

@article{Kwapiszewski2012,
  author = {Radosław Kwapiszewski and Michał Chudy and Artur Dybko and Zbigniew Brzózka},
  title = {Development of a Point-of-Care system for early diagnostics of genetic diseases},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {6--8},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/84-development-of-a-point-of-care-system-for-early-diagnostics-of-genetic-diseases}
}
Promotion of iron-oxide with potassium as optimization of the soot combustion catalyst
Author:
Piotr Legutko, Paweł Stelmachowski, Andrzej Kotarba
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5 x
 

 

Abstract: In this work the eff ect of potassium addition to iron oxides (FeO, Fe3O4, Fe2O3) as catalysts for soot combustion was investigated. While the addition of potassium by impregnation had positive eff ect on all oxides the strength of this eff ect varied considerably. Comparison with potassium ferrites (K2Fe22O34, KFeO2), with potassium as a part of a crystal lattice, proved that they were more active than unpromoted oxides. Th e determined range of activity was as follows: FeO < Fe3O4 Fe2O3 K/Fe34 ~ K2Fe22O34 K/Fe2O3 K/FeO ~FeO2.

Keywords: soot combustion, promotion, potassium, iron, ferrite, catalyst

Area: Nanotechnologies and Materials

BibTeX:

@article{Legutko2012,
  author = {Piotr Legutko and Paweł Stelmachowski and Andrzej Kotarba},
  title = {Promotion of iron-oxide with potassium as optimization of the soot combustion catalyst},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {9--11},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/85-promotion-of-iron-oxide-with-potassium-as-optimization-of-the-soot-combustion-catalyst}
}
Structure and phase structure of electro-spark Zr coatings on titanium alloys
Author:
Iryna Smolina
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3 x
 

 

Abstract: The article is cover investigation microstructure and phase composition of electro-spark Zr-coatings on titanium base. Coatings were obtained in protective (Ar) and saturation (N2)  atmosphere. Th e properties of coatings were investigated by SEM and X-ray diff raction, microstructure and microhardness analysis. It has been shown that microhardness increase till 16 GPa in intermediate layer after ESA in saturation atmosphere.

Keywords: titanium alloys, electro-spark alloying (ESA), coatings, microhardness, microstructure, SEM

Area: Nanotechnologies and Materials

BibTeX:

@article{Smolin2012,
  author = {Iryna Smolina},
  title = {Structure and phase structure of electro-spark Zr coatings on titanium alloys},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {12--14},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/86-structure-and-phase-structure-of-electro-spark-zr-coatings-on-titanium-alloys}
}
Preparation of silver core nanoparticles with polysaccharide shell
Author:
Iga Wasiak, Tomasz Ciach
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9 x
 

 

Abstract: The objective of the present study was to obtain silver core nanoparticles coated with dextran shell. In the described method dextran plays role of reductive and protective agent and also functionalisation ligand. Our research was aimed at nanoparticles synthesis at 37°C. It is the human body temperature, which is safe for temperature-sensitive drugs (proteins). In the presented work the time of reaction, dextran molecular weight and its chemical functionalisation was investigated. Particles were characterized by Nanosight and SEM, their UV–Vis spectroscopic absorption properties were also determined. Nanoparticles with diameter less than 95 nm with relatively narrow size distribution were obtained. Our work demonstrated that it was possible to obtain nanoparticles in 37°C without using any harmful reagents.

Keywords: silver nanoparticles, dextran, polyaldehydodextran

Area: Nanotechnologies and Materials

BibTeX:

@article{Wasiak2012,
  author = {Iga Wasiak and Tomasz Ciach},
  title = {Preparation of silver core nanoparticles with polysaccharide shell},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {15--17},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/87-preparation-of-silver-core-nanoparticles-with-polysaccharide-shell}
}
The Effect of Fertilizer Application of Granulated Organic-Mineral Fertilizers Formed from Spent Mushroom Substrate on Crop of Common Cabbage (Brassica oleracea L.)
Author:
Ewa Kuśmirek, Michał Hoch, Agnieszka Czopowicz
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9 x
 

 

Abstract: The aim the research is to estimate the infl uence of granulated organic-mineral fertilizers formed from spent mushroom substrate (SMS) on the common cabbage crop. Fertilizers and composted spent mushroom substrate are using on two doses on account of applicationed nitrogen content, these doses are 100 and 200 kg N ha-1. 10 fertilizers combinations on four replications are used in experiment. Th e test plant was common cabbage. After harvest were estimated yield of green matter and dry matter yield. Statgraphics 4.0. program was using to statistic data processing of the results. Dry matter yield of cabbage depends on the kind and dose of fertilizers applied in the  experiment. The greatest yields are obtained from object manured by fertilizer formed from spent mushroom substrate with supplement urea and powdery superphosphate and potassium salt, also fertilizer formed from spent mushroom substrate with supplement ammonium salpeter. Other granuled organic-mineral fertilizers have a positive infl uence on increasing cabbage yield in comparison to the control object, however, their yield eff ect is similar.

Keywords: organic-mineral fertilizers, spent mushroom substrate, common cabbage

Area: Natural Sciences

BibTeX:

@article{Kusmirek2012,
  author = {Ewa Kuśmirek and Michał Hoch and Agnieszka Czopowicz},
  title = {The Effect of Fertilizer Application of Granulated Organic-Mineral Fertilizers Formed from Spent Mushroom Substrate on Crop of Common Cabbage (Brassica oleracea L.)},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {18--22},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/88-the-effect-of-fertilizer-application-of-granulated-organic-mineral-fertilizers-formed-from-spent-mushroom-substrate-on-crop-of-common-cabbage-brassica-oleracea-l}
}
The importance of the economic evaluation of dispersed power generation in the pre-investment phase — agricultural biogas plants
Author:
Anna Oniszk-Popławska
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11 x
 

 

Abstract: In the case of dispersed power generation, such as renewable energy sources (RES), the investment risks are much higher than for fossil fuels. Higher are also the specifi c investment costs per MWel of installed power capacity. Th erefore, the pre-investment phase for such projects should be elaborated with due diligence. In particular it refers to emerging market technologies, where there has been little or no record of their development in the past. Despite various support schemes, a professional feasibility study is not to be aff orded by smaller investors. Th erefore, other simplifi ed tools must be made available for them, especially in the pre-investment phase. In this article agricultural biogas plants (ABP) were chosen to exemplify the complexity of the technoeconomic evaluation of dispersed generation in the pre-feasibility phase.

Keywords: economic evaluation, opportunity study, pre-feasibility study, agricultural biogas, renewable energy sources, dispersed power generation

Area: Natural Sciences

BibTeX:

@article{Poplawsk2012,
  author = {Anna Oniszk-Popławska},
  title = {The importance of the economic evaluation of dispersed power generation in the pre-investment phase — agricultural biogas plants},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {23--31},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/89-the-importance-of-the-economic-evaluation-of-dispersed-power-generation-in-the-pre-investment-phase-agricultural-biogas-plants}
}
The concept of a central system collecting data on the use of the environment
Author:
Mariusz Rogulski
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5 x
 

 

Abstract: The article presents the current stage of development of the process of collecting data on the use of the environment by entities using environment and also identifi es its weak areas. Setting up a central information system is suggested; its task would be to collect consistent data on emissions and to share the data with all stakeholders. Basic assumptions to be fulfi lled by the system are proposed that would improve the task of reporting for operators as well as for those who collect and process data.

Keywords: central information and IT systems, environment data, emission data, information flows

Area: Natural Sciences

BibTeX:

@article{Rogulski2012,
  author = {Mariusz Rogulski},
  title = {The concept of a central system collecting data on the use of the environment},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {32--36},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/90-the-concept-of-a-central-system-collecting-data-on-the-use-of-the-environment}
}
Numerical modelling of a test embankment on soft ground
Author:
Katarzyna Gabryś
Downloads:
18 x
 

 

Abstract: The construction of an embankment situated on soft subsoil with a high groundwater level leads to a rise in pore pressure. This “undrained behaviour” can made the eff ective stress to remain low and intermediate consolidation periods to be adopted so that the construction of the embankment is safe. During a consolidation process the dissipation of the excess pore pressure is observed in order to increase the shear strength of the soil to continue the construction process [4]. The behaviour of a test embankment founded on a soft soil in Warsaw, on the Ursynowska Scarp, in the Campus SGGW (Warsaw University of Life Sciences) site was simulated with a use of a fi nite element analysis [6]. This study presents an experimental work, a construction of a fl ood-control embankment on organic soil represented by peat. Th e modelling of an embankment behaviour is carried out by the program PLAXIS (Finite Element Code for Soil and Rock Analysis). Measurements were taken of pore pressure, dissipations rates and displacements in the foundation peat. Predictions of these were made using
a simple Soft Soil Model. Moreover, the calculation of the safety factor, the eff ect of the drains on the consolidation process and an update mesh analysis were investigated.
Th e results suggest the signifi cant impact of drains on the speed of the consolidation course. Th e commonly accepted Mohr-Coulomb Model and Soft Soil Model, which involve typical parameters obtained from in-situ and laboratory testing, can be successfully selected for examination the behaviour of fl ood-control embankment situated on soft soils. The Updated mesh and Updated water pressure analysis reduces the settlements and allows for a more realistic study of settlements, while the positive effects of large deformations is considered. However, there is a great need to compare the numerical simulation with the real existing embankments located on problematic soils.

Keywords: numerical modelling, embankment construction, soft soil

Area: Town and Urban Planning, Architecture and Building Engineering

BibTeX:

@article{Gabrys2012,
  author = {Katarzyna Gabryś},
  title = {Numerical modelling of a test embankment on soft ground},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {37--43},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/91-numerical-modelling-of-a-test-embankment-on-soft-ground}
}
Influence of the slipe effect on simply supported composite beam
Author:
Tomasz Pytlowany
Downloads:
8 x
 

 

Abstract: The work concerns the slip eff ect which may occur in simply supported composite beams. Th e occurrence of the slip eff ect may lead to additional increase in beam defl ection. The main reason for the increase is susceptibility of the anchor bolts that join the beam. Th e analysis of the slip eff ect occurrence is based on the following criteria: steel and concrete are linearly elastic, junction goes along the whole length of the considered beam, concrete slab and steel rib move by the same value along the whole length of the beam, simply supported beams are analysed. In order to present the slip eff ect in composite beams and its results, a numerical example is used. The example shows three kinds of the load capacity of anchor bolts as well as their impact on the slip eff ect and defl ection of steel-concrete composite beams.

Keywords: slip effect, composite beams, simply supported beams

Area: Town and Urban Planning, Architecture and Building Engineering

BibTeX:

@article{Pytlowany2012,
  author = {Tomasz Pytlowany},
  title = {Influence of the slipe effect on simply supported composite beam},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {44--49},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/92-influence-of-the-slipe-effect-on-simply-supported-composite-beam}
}
Bionics in architecture
Author:
Anzhela Zakharchuk
Downloads:
248 x
 

 

Abstract: The usage of forming principles of wild life got the new quality and received a name of architectural and bionic process and became one of the trends of architecture in the world architectural practice for the last 40 years. Bionics is an innovative architectural style that took all the best from nature: relief outlines and forms. It can be called architecture of future and its aim is synthesis of nature and modern technologies.

Keywords: architectural bionics, bionic style, forms of wildlife, organic architecture, synthesis of nature and technology

Area: Town and Urban Planning, Architecture and Building Engineering

BibTeX:

@article{Zakharchuk2012,
  author = {Andrzej Zakharchuk},
  title = {Bionics in architecture},
  journal = {Challenges of Modern Technology},
  year = {2012},
  volume = {3},
  number = {2},
  pages = {50--53},
  url = {http://www.journal.young-scientists.eu/index.php/isuues/file/93-bionics-in-architecture}
}
 
 
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